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Abstract <p>The synthesis of heterocyclic and mono- and dicarboxamide compounds of various structures and functional substitutions was performed by electrophilic reactions, using chlorides of cyclohexane(ene)-, 1-methylcyclohexane(ene)-, and 5-phenyldodecacarboxylic and their isostructural aliphatic carboxylic acids as acylating reagents and aromatic mono- and difunctionally substituted mono- and aliphatic amines as substrates. <i>N</i>-Cycloacyl derivatives of benzimidazole were obtained for the first time by the acylation of benzimidazole with cyclohex-3-ene(an)-1-methylcyclohex-3-ene(an)carboxylic acid chlorides. The acylation of <i>o</i>-phenylenediamine with corresponding acid chrolides was used to prepare <i>N</i>-alkyl and <i>N</i>-acyl, as well as <i>C</i>-acyl benzimidazole derivatives. Saturated cyclohexane- and 1-methylcyclohexanecarboxylic acids and their chlorides were prepared by the hydrogenation of the corresponding unsaturated cyclohexane-3-ene- and 1-methylcyclohex-3-enecarboxylic acids.</p>

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Synthesis of Cyclohex-3-en(ane)-, 1-Methylcyclohex-3-en(ane)-, and 5-Alkylphenyl-substituted Dodecacarboxylic Acids

  • 期刊论文

  • 发表日期：

    2025年2月1日

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  • G. A. Mirzoyeva,
  • Sh. M. Eyvazova

摘要

Abstract

The synthesis of heterocyclic and mono- and dicarboxamide compounds of various structures and functional substitutions was performed by electrophilic reactions, using chlorides of cyclohexane(ene)-, 1-methylcyclohexane(ene)-, and 5-phenyldodecacarboxylic and their isostructural aliphatic carboxylic acids as acylating reagents and aromatic mono- and difunctionally substituted mono- and aliphatic amines as substrates. N-Cycloacyl derivatives of benzimidazole were obtained for the first time by the acylation of benzimidazole with cyclohex-3-ene(an)-1-methylcyclohex-3-ene(an)carboxylic acid chlorides. The acylation of o-phenylenediamine with corresponding acid chrolides was used to prepare N-alkyl and N-acyl, as well as C-acyl benzimidazole derivatives. Saturated cyclohexane- and 1-methylcyclohexanecarboxylic acids and their chlorides were prepared by the hydrogenation of the corresponding unsaturated cyclohexane-3-ene- and 1-methylcyclohex-3-enecarboxylic acids.