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Abstract <p>The functionalization of 1-acetylnaphthalene (<b>1</b>) through the reaction with dimethylformamide dimethyl acetal resulted in the formation of 3-(dimethylamino)-1-(naphthalen-1-yl)prop-2-en-1-one (<b>2</b>) which reacted with substituted aminopyrazoles <b>3</b> in the presence of KHSO<sub>4</sub> in aqueous media under ultrasonic irradiation, yielding novel substituted 7-(naphthalen-1-yl)pyrazolo[1,5-<i>a</i>]pyrimidine derivatives <b>4a</b> and <b>4b</b>. The structures of these compounds were confirmed by analytical and spectral data, as well as by X-ray crys­tallo­graphic analysis of compound <b>4b</b>.</p>

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A Facile Environment-Friendly Synthesis of 7-(Naphthalen-1-yl)­pyrazolo[1,5-a]pyrimidine Analogues via Aza-Michael Addition–Elimination–Cyclodehydration. X-Ray Crystallography and Structural Elucidation

  • 期刊论文

  • 发表日期：

    2025年3月1日

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  • T. R. A. Sangma,
  • D. K. Lamin,
  • T. S. Sangma,
  • C. R. Marak,
  • L. B. Marpna,
  • S. Kaping,
  • J. N. Vishwakarma

摘要

Abstract

The functionalization of 1-acetylnaphthalene (1) through the reaction with dimethylformamide dimethyl acetal resulted in the formation of 3-(dimethylamino)-1-(naphthalen-1-yl)prop-2-en-1-one (2) which reacted with substituted aminopyrazoles 3 in the presence of KHSO4 in aqueous media under ultrasonic irradiation, yielding novel substituted 7-(naphthalen-1-yl)pyrazolo[1,5-a]pyrimidine derivatives 4a and 4b. The structures of these compounds were confirmed by analytical and spectral data, as well as by X-ray crys­tallo­graphic analysis of compound 4b.