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Abstract <p>The reaction of substituted dinitroacetonitrile with isoquinoline in the presence of dimethyl but-2-yne-1,4-dioate involves 1,3-dipolar cycloaddition to form a mixture of diastereomeric dimethyl 2-(dinitromethyl)-1,1<i>bH</i>-pyrimido[2,1-<i>a</i>]isoquinoline-3,4-dicarboxylates. The synthesized compounds can be considered as promising synthons with potential antitubercular and fungicidal activity.</p>

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Reaction of Substituted Dinitroacetonitriles with Isoquinoline in the Presence of Dimethyl But-2-yne-1,4-dioate

  • 期刊论文

  • 发表日期：

    2025年2月1日

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  • A. G. Tyrkov,
  • Е. А. Yurtaeva

摘要

Abstract

The reaction of substituted dinitroacetonitrile with isoquinoline in the presence of dimethyl but-2-yne-1,4-dioate involves 1,3-dipolar cycloaddition to form a mixture of diastereomeric dimethyl 2-(dinitromethyl)-1,1bH-pyrimido[2,1-a]isoquinoline-3,4-dicarboxylates. The synthesized compounds can be considered as promising synthons with potential antitubercular and fungicidal activity.