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Abstract <p>The reaction of previously reported 4-(1,4-benzodioxan-6-yl)tetrahydro-2<i>H</i>-pyran-4-carbonyl chloride with hydrazine hydrate gave symmetrical diacylhydrazine which was cyclized to 2,5-bis[4-(1,4-benzodioxan-6-yl)tetrahydro-2<i>H</i>-pyran-4-yl]-1,3,4-oxadiazole by the action of phosphoryl chloride. Unsym­metrical 2,5-disubstituted 1,3,4-oxadiazoles were synthesized by the condensation of 4-(1,4-benzodioxan-6-yl)­tetrahydro-2<i>H</i>-pyran-4-carbonyl chloride with various acid hydrazides, followed by cyclization of the resulting diacylhydrazines with phosphoryl chloride. The synthesized compounds were evaluated for their antiarrhythmic activity.</p>

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Synthesis and Antiarrhythmic Activity of New 1,3,4-Oxadiazole Derivatives Containing a 1,4-Benzodioxane Fragment

  • 期刊论文

  • 发表日期：

    2025年1月1日

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  • A. S. Avagyan,
  • S. O. Vardanyan,
  • A. B. Sargsyan,
  • H. A. Panosyan,
  • G. S. Mkrtchyan,
  • H. E. Tumajyan,
  • R. E. Muradyan,
  • A. A. Aghekyan

摘要

Abstract

The reaction of previously reported 4-(1,4-benzodioxan-6-yl)tetrahydro-2H-pyran-4-carbonyl chloride with hydrazine hydrate gave symmetrical diacylhydrazine which was cyclized to 2,5-bis[4-(1,4-benzodioxan-6-yl)tetrahydro-2H-pyran-4-yl]-1,3,4-oxadiazole by the action of phosphoryl chloride. Unsym­metrical 2,5-disubstituted 1,3,4-oxadiazoles were synthesized by the condensation of 4-(1,4-benzodioxan-6-yl)­tetrahydro-2H-pyran-4-carbonyl chloride with various acid hydrazides, followed by cyclization of the resulting diacylhydrazines with phosphoryl chloride. The synthesized compounds were evaluated for their antiarrhythmic activity.