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Abstract <p>The synthesis of <i>N</i>-benzoylmethylamides of <i>N</i>-substituted α,β-dehydroamino acids and the corresponding 4<i>H</i>-imidazol-4-ones was carried out; their antibacterial, antifungal, and antiradical properties were studied. It was shown that among them, the compounds containing a nitro group in the <i>meta</i>- or <i>para</i>-position of the benzene ring of the arylidene residue exhibited the highest activity against <i>E. coli</i>, <i>St. aureus</i>, and <i>Candida albicans</i>.</p>

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Synthesis and Study of Antimicrobial and Antiradical Activity of N-Benzoylmethylamides of N-Substituted α,β-Dehydroamino Acids and the Corresponding Imidazol-4-ones

  • 期刊论文

  • 发表日期：

    2026年7月23日

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  • Asmik G. Agababyan,
  • Anna G. Sukiasyan,
  • Armen A. Hovhannisyan,
  • Astghik A. Shahkhatuni,
  • Sirvard G. Mangasaryan,
  • Roza A. Madoyan,
  • Samvel G. Chailyan,
  • Vigen O. Topuzyan

摘要

Abstract

The synthesis of N-benzoylmethylamides of N-substituted α,β-dehydroamino acids and the corresponding 4H-imidazol-4-ones was carried out; their antibacterial, antifungal, and antiradical properties were studied. It was shown that among them, the compounds containing a nitro group in the meta- or para-position of the benzene ring of the arylidene residue exhibited the highest activity against E. coli, St. aureus, and Candida albicans.