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Abstract <p>A successful one-pot, multicomponent, and eco-efficient technique has been developed for the construction of 2-amino-alkoxypyridine-3,5-dicarbonitriles. This reaction entails a tandem pseudo-three-component process employing arylaldehyde, dicyanomethane, and alcohol (methanol, ethanol, or propanol), catalyzed by [bmim]OH at 80°C. This synthetic approach is characterized by its consistently high yields (85–92%), as well as its simple, more efficient, low-cost, column-free chromatography, solvent-free, and lesser reaction periods (120–160 min). The method not only streamlines the production process but also enhances the diversity of accessible derivatives and their subsequent applications in medicinal chemistry. 3BL6 protein of bacteria is screened for drug-likeness properties for synthesized compounds.</p>

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Economically Feasible Multicomponent Construction of Diverse 2-Amino-alkoxypyridine-3,5-dicarbonitriles Using [BMIM]OH as a Catalyst and Their Docking Studies

  • 期刊论文

  • 发表日期：

    2026年6月15日

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  • Phani Madhuri,
  • Sathyanarayana Boodida

摘要

Abstract

A successful one-pot, multicomponent, and eco-efficient technique has been developed for the construction of 2-amino-alkoxypyridine-3,5-dicarbonitriles. This reaction entails a tandem pseudo-three-component process employing arylaldehyde, dicyanomethane, and alcohol (methanol, ethanol, or propanol), catalyzed by [bmim]OH at 80°C. This synthetic approach is characterized by its consistently high yields (85–92%), as well as its simple, more efficient, low-cost, column-free chromatography, solvent-free, and lesser reaction periods (120–160 min). The method not only streamlines the production process but also enhances the diversity of accessible derivatives and their subsequent applications in medicinal chemistry. 3BL6 protein of bacteria is screened for drug-likeness properties for synthesized compounds.