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Abstract <p>A series of 1,3-disubstituted ureas was synthesized in 85–93% yield by the reaction of 2-(1-isocyanatoethyl)-6-methoxynaphthalene with adamantyl-containing, cyclic, and aromatic amines. The synthesized ureas are promising inhibitors of human soluble epoxide hydrolase (sEH) and potential inhibitors of cyclooxygenase (COX-2).</p>

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Synthesis and Properties of 1,3-Disubstituted Ureas Based on a Naphthyl Propionic Acid Derivative Naproxen

  • 期刊论文

  • 发表日期：

    2026年3月23日

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  • Vladimir S. Dyachenko,
  • Boris P. Gladkikh,
  • Abdulhamid Hussein Abdullah Al-Fanharawi,
  • Alexey D. Averin,
  • Gennady M. Butov,
  • Ivan A. Novakov

摘要

Abstract

A series of 1,3-disubstituted ureas was synthesized in 85–93% yield by the reaction of 2-(1-isocyanatoethyl)-6-methoxynaphthalene with adamantyl-containing, cyclic, and aromatic amines. The synthesized ureas are promising inhibitors of human soluble epoxide hydrolase (sEH) and potential inhibitors of cyclooxygenase (COX-2).