Scholarlink

Abstract <p>The complexation ability of one of the new promising analgesics, thiowurtzine (TW), with a number of cyclodextrin (CD) host molecules was studied using electron and <sup>1</sup>H NMR spectroscopy in methanol and confirmed by quantum-chemical and molecular dynamics calculations. Spectrophotometric and fluorescence titration methods determined the 1 : 1 stoichiometry and stability of the resulting complexes with γ-cyclodextrin derivatives (for TW@HP-γ-CD log <i>K</i><sub>1:1</sub> = 3.0).</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Study of the Complexation of Thiowurtzine with Cyclodextrins

  • 期刊论文

  • 发表日期：

    2026年3月19日

查看全文
  • Natalia A. Lobova,
  • Anastasiya V. Aleksandrova,
  • Evgeny S. Medyantsev,
  • Alexander A. Aleхandrov,
  • Vitaly G. Avakyan,
  • Sergey V. Titov,
  • Sergey Z. Vatsadze

摘要

Abstract

The complexation ability of one of the new promising analgesics, thiowurtzine (TW), with a number of cyclodextrin (CD) host molecules was studied using electron and 1H NMR spectroscopy in methanol and confirmed by quantum-chemical and molecular dynamics calculations. Spectrophotometric and fluorescence titration methods determined the 1 : 1 stoichiometry and stability of the resulting complexes with γ-cyclodextrin derivatives (for TW@HP-γ-CD log K1:1 = 3.0).