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Abstract <p>The synthesis of 4-(2′-phenylethyn-1′-yl)-<i>O</i>,<i>O</i>-diethylphosphonate, 4-(2′-phenylethyn-1′-yl)phosphine, and the corresponding 1,5-diaza-3,7-diphosphacyclooctane was presented. The reaction products were characterized by NMR spectroscopy. The conducted studies showed that 4-iodophenylphosphonate is a convenient reagent that undergoes functionalization via C–C cross-coupling reactions, enabling the synthesis of a wide range of functionalized phosphonates, phosphines, and their derivatives.</p>

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Functionalization of 4-Iodophenyl-O,O-diethylphosphonate via the Sonogashira Cross-Coupling Reaction as a Route to New Primary Phosphines and 1,5-Diaza-3,7-diphosphacyclooctanes

  • 期刊论文

  • 发表日期：

    2026年3月14日

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  • Irina R. Dayanova,
  • Roman M. Kuzmin,
  • Alexey V. Kurenkov,
  • Kamil D. Akhmadgaleev,
  • Elvira I. Musina,
  • Igor D. Strelnik,
  • Andrey A. Karasik

摘要

Abstract

The synthesis of 4-(2′-phenylethyn-1′-yl)-O,O-diethylphosphonate, 4-(2′-phenylethyn-1′-yl)phosphine, and the corresponding 1,5-diaza-3,7-diphosphacyclooctane was presented. The reaction products were characterized by NMR spectroscopy. The conducted studies showed that 4-iodophenylphosphonate is a convenient reagent that undergoes functionalization via C–C cross-coupling reactions, enabling the synthesis of a wide range of functionalized phosphonates, phosphines, and their derivatives.