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Abstract <p>A series of 1,2,3-triazole nucleoside analogues containing an <i>N</i>-acetyl-D-glucosamine residue was synthesized via copper-catalyzed azide-alkyne cycloaddition of 3,4,6-tri-<i>O</i>-acetyl-2-deoxy-2-acetamido-β-D-glucopyranosyl azide with <i>N</i>-propargyl derivatives of phenothiazine, carbazole, isatin, phthalimide, and imidazolin-2-one. The synthesized compounds demonstrated moderate in vitro cytotoxicity against human cancer cell lines M-HeLa, MCF-7, PANC-1, PC-3, T 98G, A 549, and HuTu 80.</p>

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1,2,3-Triazole Nucleoside Analogues with a N-Acetyl-D-glucosamine Residue. Synthesis and Cytotoxic Activity

  • 期刊论文

  • 发表日期：

    2026年2月26日

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  • Ravil F. Aznagulov,
  • Leysan R. Safargalieva,
  • Bulat F. Garifullin,
  • Andrey V. Bogdanov,
  • Almir S. Gazizov,
  • Anna P. Lyubina,
  • Alexandra D. Voloshina,
  • Olga V. Andreeva,
  • Maya G. Belenok,
  • Vladimir E. Kataev

摘要

Abstract

A series of 1,2,3-triazole nucleoside analogues containing an N-acetyl-D-glucosamine residue was synthesized via copper-catalyzed azide-alkyne cycloaddition of 3,4,6-tri-O-acetyl-2-deoxy-2-acetamido-β-D-glucopyranosyl azide with N-propargyl derivatives of phenothiazine, carbazole, isatin, phthalimide, and imidazolin-2-one. The synthesized compounds demonstrated moderate in vitro cytotoxicity against human cancer cell lines M-HeLa, MCF-7, PANC-1, PC-3, T 98G, A 549, and HuTu 80.