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Abstract <p>A new hybrid organic ligand with 2-(2-pyridyl)benzothiazoles and catechol fragments was synthesized and studied in the complexation reaction with copper(II) chloride. Synthesis conditions that allow for obtaining a complex in which copper coordination is carried out by the pyridylbenzothiazole fragment, and the catechol fragment does not participate in the coordination, have been determined. To find the possibility and optimal conditions for a complex without coordination of catechol formation, DFT calculation data were used. The structure of the obtained coordination compound with LCuCl<sub>2</sub> composition was established using as elemental analysis, UV-Vis spectroscopy, cyclic voltammetry and total X-ray scattering with pair distribution function analysis. Measurement of cytotoxicity and the ability to reactive oxygen species (ROS) generation for synthesized complex on MCF-7 cell lines demonstrated reasonable cytotoxicity of 5 µМ, not associated with ROS formation.</p>

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Сopper(II) Complex with a Hybrid Molecule Containing Pyridylbenzothiazole and Catechol Fragments without Catechol Coordination

  • 期刊论文

  • 发表日期：

    2026年2月9日

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  • Maksim S. Abramovich,
  • Dmitriy M. Tsymbarenko,
  • Mikhail P. Kendin,
  • Anna A. Moiseeva,
  • Aleksandr N. Vaneev,
  • Aleksandr S. Erofeev,
  • Yuri V. Timchenko,
  • Igor A. Rodin,
  • Anna V. Berezina,
  • Nikolay V. Zyk,
  • Elena K. Beloglazkina,
  • Elena S. Barskaya

摘要

Abstract

A new hybrid organic ligand with 2-(2-pyridyl)benzothiazoles and catechol fragments was synthesized and studied in the complexation reaction with copper(II) chloride. Synthesis conditions that allow for obtaining a complex in which copper coordination is carried out by the pyridylbenzothiazole fragment, and the catechol fragment does not participate in the coordination, have been determined. To find the possibility and optimal conditions for a complex without coordination of catechol formation, DFT calculation data were used. The structure of the obtained coordination compound with LCuCl2 composition was established using as elemental analysis, UV-Vis spectroscopy, cyclic voltammetry and total X-ray scattering with pair distribution function analysis. Measurement of cytotoxicity and the ability to reactive oxygen species (ROS) generation for synthesized complex on MCF-7 cell lines demonstrated reasonable cytotoxicity of 5 µМ, not associated with ROS formation.