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Abstract <p>The search for new classes of agrochemicals is a key task of modern agrochemistry due to the growing resistance of phytopathogens and stricter environmental requirements for pesticides. In this work, the antimicrobial activity of a number of synthesized α,β-bis(diphenylphosphinoxide)ethanes against economically significant phytopathogens was investigated. Antimicrobial activity was assessed by serial micro-dilution in broth to determine the minimum inhibitory (MIC) and fungicidal/bactericidal (MFC/MBC) concentrations. To assess the effect of solubility on biological activity, studies were conducted in two solvent systems: 5 and 50% aqueous ethanol. In a system with 5% ethanol, most compounds showed no activity against <i>Fusarium graminearum</i> and <i>Alternaria alternata</i> fungi. However, with an increase in ethanol concentration to 50%, compounds [1-(2-fluorophenyl)ethane-1,2-diyl]bis(diphenylphosphine oxide) and (1-phenylhexane-1,2-diyl)bis(diphenylphosphine oxide) demonstrated pronounced fungicidal activity against <i>F. graminearum</i> (MIC = 312 μg/mL). The highest antibacterial activity was recorded for (1-phenylhexane-1,2-diyl)bis(diphenylphosphine oxide), especially against the gram-negative bacterium <i>Erwinia carotovora</i> (MIC = 19 μg/mL), which significantly exceeds the performance of the reference drug chloramphenicol (MIC = 312 μg/mL). Thus, the compounds studied, especially bisphosphine oxide with a long alkyl substituent, have demonstrated high potential as antibacterial agents. The dependence of their fungicidal activity on solubility was revealed. [1-(2-Fluorophenyl)ethane-1,2-diyl]bis(diphenylphosphine oxide) is a promising leader structure for the further development of new plant protection products.</p>

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Antibacterial and Fungicidal Activities of Some 1,2-Bis(diphenylphosphine oxide)ethanes Against Plant Phytopathogens

  • 期刊论文

  • 发表日期：

    2026年2月26日

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  • Maxim V. Tarasov,
  • Tatyana V. Gryaznova,
  • Lilia M. Davydova,
  • Evgeny N. Nikitin,
  • Yulia H. Budnikova

摘要

Abstract

The search for new classes of agrochemicals is a key task of modern agrochemistry due to the growing resistance of phytopathogens and stricter environmental requirements for pesticides. In this work, the antimicrobial activity of a number of synthesized α,β-bis(diphenylphosphinoxide)ethanes against economically significant phytopathogens was investigated. Antimicrobial activity was assessed by serial micro-dilution in broth to determine the minimum inhibitory (MIC) and fungicidal/bactericidal (MFC/MBC) concentrations. To assess the effect of solubility on biological activity, studies were conducted in two solvent systems: 5 and 50% aqueous ethanol. In a system with 5% ethanol, most compounds showed no activity against Fusarium graminearum and Alternaria alternata fungi. However, with an increase in ethanol concentration to 50%, compounds [1-(2-fluorophenyl)ethane-1,2-diyl]bis(diphenylphosphine oxide) and (1-phenylhexane-1,2-diyl)bis(diphenylphosphine oxide) demonstrated pronounced fungicidal activity against F. graminearum (MIC = 312 μg/mL). The highest antibacterial activity was recorded for (1-phenylhexane-1,2-diyl)bis(diphenylphosphine oxide), especially against the gram-negative bacterium Erwinia carotovora (MIC = 19 μg/mL), which significantly exceeds the performance of the reference drug chloramphenicol (MIC = 312 μg/mL). Thus, the compounds studied, especially bisphosphine oxide with a long alkyl substituent, have demonstrated high potential as antibacterial agents. The dependence of their fungicidal activity on solubility was revealed. [1-(2-Fluorophenyl)ethane-1,2-diyl]bis(diphenylphosphine oxide) is a promising leader structure for the further development of new plant protection products.