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Abstract <p>A method for the direct introduction of 2-(R-phenacyl)methyl-5-aryl(heteryl)tetrazole fragments into the molecule of 2-R-6-nitro-1,2,4-triazolo[1,5-a]pyrimidines via a nucleophilic addition reaction has been developed. The antimicrobial activity of some synthesized compounds was evaluated against the reference strain <i>Neisseria gonorrhoeae</i> ATCC 49226/NCTC 12700 and museum strains of dermatophyte and yeast-like fungi.</p>

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σH-Adducts of 2-R-6-Nitro-1,2,4-triazolo[1,5-a]pyrimidines Containing a 2,5-Disubstituted Tetrazole Fragment in the Molecule

  • 期刊论文

  • 发表日期：

    2025年11月1日

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  • E. B. Gorbunov,
  • R. I. Ishmetova,
  • A. A. Tumashov,
  • N. A. Gerasimova,
  • N. P. Evstigneeva,
  • G. L. Rusinov

摘要

Abstract

A method for the direct introduction of 2-(R-phenacyl)methyl-5-aryl(heteryl)tetrazole fragments into the molecule of 2-R-6-nitro-1,2,4-triazolo[1,5-a]pyrimidines via a nucleophilic addition reaction has been developed. The antimicrobial activity of some synthesized compounds was evaluated against the reference strain Neisseria gonorrhoeae ATCC 49226/NCTC 12700 and museum strains of dermatophyte and yeast-like fungi.