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Abstract <p>The acid-catalyzed reaction of 1,1-diethoxypropane derivatives with 2-naphthol, 2,7-naphthalenediol, and sesamol leads to the formation of new diarylmethanes and dibenzoxanthenes. The proposed method allows for the relatively facile introduction of the required functional group into the propylene fragment. Cytotoxic activity of all synthesized compounds was studied against normal and human cancer cell lines. Structures of the obtained compounds were confirmed by NMR (<sup>1</sup>H, <sup>31</sup>P, <sup>13</sup>C) and single crystal X-ray diffraction analysis.</p>

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Synthesis of New Derivatives of Diarylmethane, Dibensoxanthene and Evaluation of Their Antitumor Activity

  • 期刊论文

  • 发表日期：

    2025年10月31日

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  • Karina O. Shibaeva,
  • Andrey V. Smolobochkin,
  • Al’mir S. Gazizov,
  • Daria P. Gerasimova,
  • Aleksandra D. Voloshina,
  • Anna P. Lyubina,
  • Andrey A. Parfenov,
  • Aleksandr R. Burilov,
  • Mikhail A. Pudovik

摘要

Abstract

The acid-catalyzed reaction of 1,1-diethoxypropane derivatives with 2-naphthol, 2,7-naphthalenediol, and sesamol leads to the formation of new diarylmethanes and dibenzoxanthenes. The proposed method allows for the relatively facile introduction of the required functional group into the propylene fragment. Cytotoxic activity of all synthesized compounds was studied against normal and human cancer cell lines. Structures of the obtained compounds were confirmed by NMR (1H, 31P, 13C) and single crystal X-ray diffraction analysis.