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Abstract <p>A wide range of pyridoxine derivatives containing vinyl groups at various positions of the pyridine ring were obtained via a three- to ten-step synthesis. Pyridoxine derivatives containing an aromatic hydroxyl and a vinyl group at the second or sixth position of the pyridine ring exhibit high antioxidant activity, which in some cases is comparable to the reference antioxidants such as quercetin, ascorbic acid, and trolox. Cytotoxic activity of the obtained compounds was studied against two conditionally normal and three tumor cell lines.</p>

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Synthesis and Biological Activity of Vinyl Derivatives of Pyridoxine

  • 期刊论文

  • 发表日期：

    2025年10月31日

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  • R. M. Khaziev,
  • E. A. Platonova,
  • O. V. Bondar,
  • A. S. Khristolyubova,
  • R. M. Vafina,
  • O. I. Gnezdilov,
  • D. Yu. Grishaev,
  • M. V. Pugachev,
  • E. I. Romanova,
  • Yu. G. Shtyrlin

摘要

Abstract

A wide range of pyridoxine derivatives containing vinyl groups at various positions of the pyridine ring were obtained via a three- to ten-step synthesis. Pyridoxine derivatives containing an aromatic hydroxyl and a vinyl group at the second or sixth position of the pyridine ring exhibit high antioxidant activity, which in some cases is comparable to the reference antioxidants such as quercetin, ascorbic acid, and trolox. Cytotoxic activity of the obtained compounds was studied against two conditionally normal and three tumor cell lines.