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Abstract <p>Eight novel coordination compounds of nickel(II), cobalt(III), and iron(III) with 4,<i>S</i>-diallylisothiosemicarbazones of 2-formylpyridine (HL<sup>1</sup>) and 2-acetylpyridine (HL<sup>2</sup>) were synthesized: [Ni(HL<sup>1</sup>)<sub>2</sub>](NO<sub>3</sub>)<sub>2</sub>, [Ni(HL<sup>2</sup>)<sub>2</sub>](NO<sub>3</sub>)<sub>2</sub>∙2H<sub>2</sub>O, [Ni(HL<sup>1</sup>)<sub>2</sub>](I)<sub>2</sub>, [Co(L<sup>1</sup>)<sub>2</sub>]I, [Co(L<sup>2</sup>)<sub>2</sub>]I, [Fe(L<sup>1</sup>)<sub>2</sub>]NO<sub>3</sub>, [Fe(L<sup>1</sup>)<sub>2</sub>]Br, [Fe(L<sup>2</sup>)<sub>2</sub>]NO<sub>3</sub>. The isothiosemicarbazone ligands were characterized by NMR and IR spectroscopy. All coordination compounds were characterized by elemental analysis, IR spectroscopy, and molar conductivity measurements of their 1 mM solutions in methanol. Furthermore, the crystal structures of the complexes [Ni(HL<sup>1</sup>)<sub>2</sub>](NO<sub>3</sub>)<sub>2</sub>, [Ni(HL<sup>2</sup>)<sub>2</sub>](NO<sub>3</sub>)<sub>2</sub>∙2H<sub>2</sub>O, [Ni(HL<sup>1</sup>)<sub>2</sub>](I)<sub>2</sub> were determined by single-crystal X-ray diffraction (SC-XRD). The investigated complexes exhibited antibacterial, antifungal, and antiradical activity against ABTS<sup>•+</sup> cation radicals. The complexes [Ni(HL<sup>1</sup>)<sub>2</sub>](NO<sub>3</sub>)<sub>2</sub>, [Ni(HL<sup>2</sup>)<sub>2</sub>](NO<sub>3</sub>)<sub>2</sub>∙2H<sub>2</sub>O, [Co(L<sup>1</sup>)<sub>2</sub>]I, [Fe(L<sup>1</sup>)<sub>2</sub>]NO<sub>3</sub> demonstrated superior antiradical activity compared to Trolox, a standard antioxidant used in medical practice.</p>

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Synthesis, Structure, and Biological Activity of New Coordination Compounds of Selected 3d-Metals with 4,S-Diallylisothiosemicarbazones of 2-Formyl- and 2-Acetylpyridine

  • 期刊论文

  • 发表日期：

    2025年9月1日

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  • I. S. Usataia,
  • V. O. Graur,
  • P. N. Bourosh,
  • E. I. Melnic,
  • G. G. Balan,
  • C. S. Lozan-Tirsu,
  • O. S. Garbuz,
  • A. P. Gulea

摘要

Abstract

Eight novel coordination compounds of nickel(II), cobalt(III), and iron(III) with 4,S-diallylisothiosemicarbazones of 2-formylpyridine (HL1) and 2-acetylpyridine (HL2) were synthesized: [Ni(HL1)2](NO3)2, [Ni(HL2)2](NO3)2∙2H2O, [Ni(HL1)2](I)2, [Co(L1)2]I, [Co(L2)2]I, [Fe(L1)2]NO3, [Fe(L1)2]Br, [Fe(L2)2]NO3. The isothiosemicarbazone ligands were characterized by NMR and IR spectroscopy. All coordination compounds were characterized by elemental analysis, IR spectroscopy, and molar conductivity measurements of their 1 mM solutions in methanol. Furthermore, the crystal structures of the complexes [Ni(HL1)2](NO3)2, [Ni(HL2)2](NO3)2∙2H2O, [Ni(HL1)2](I)2 were determined by single-crystal X-ray diffraction (SC-XRD). The investigated complexes exhibited antibacterial, antifungal, and antiradical activity against ABTS•+ cation radicals. The complexes [Ni(HL1)2](NO3)2, [Ni(HL2)2](NO3)2∙2H2O, [Co(L1)2]I, [Fe(L1)2]NO3 demonstrated superior antiradical activity compared to Trolox, a standard antioxidant used in medical practice.