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Abstract <p>As a result of this study, the first representative of coumarin-3-carboxylic acid containing a furopyridine fragment was obtained. It was demonstrated that this coumarin-3-carboxylic acid readily forms salts with various organic amines, diamines, as well as with alkali metal cations (Na, K) and ammonia. Testing of all obtained compounds against tumor cell lines M-HeLa and HuTu 80 revealed that a number of salt structures (specifically those based on 2-aminopyridine, 2,6-diaminopyridine, or sodium) exhibit cytotoxicity comparable to the reference drug, 5-fluorouracil.</p>

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New Derivatives of Coumarin-3-carboxylic Acid Containing a Furopyridine Fragment: Synthesis and Some Properties

  • 期刊论文

  • 发表日期：

    2025年8月1日

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  • A. V. Trifonov,
  • N. O. Appazov,
  • R. Kh. Bagautdinova,
  • L. K. Kibardina,
  • M. A. Pudovik,
  • A. P. Lyubina,
  • A. D. Voloshina,
  • A. S. Gazizov,
  • A. E. Tolegen,
  • N. A. Togyzbayeva,
  • M. I. Syzdykbayev,
  • R. A. Turmanov,
  • B. M. Diyarova,
  • E. A. Chugunova,
  • A. R. Burilov

摘要

Abstract

As a result of this study, the first representative of coumarin-3-carboxylic acid containing a furopyridine fragment was obtained. It was demonstrated that this coumarin-3-carboxylic acid readily forms salts with various organic amines, diamines, as well as with alkali metal cations (Na, K) and ammonia. Testing of all obtained compounds against tumor cell lines M-HeLa and HuTu 80 revealed that a number of salt structures (specifically those based on 2-aminopyridine, 2,6-diaminopyridine, or sodium) exhibit cytotoxicity comparable to the reference drug, 5-fluorouracil.