Abstract <p>The interaction of thiourea and monochloroacetic acid in water was studied, including prolonged holding of the reaction mixture at ordinary laboratory temperature. Based on the results obtained, taking into account literature data, a scheme of the reaction transformations and probable mechanisms of cyclization of the intermediate pseudothiohygantoic acid hydrochloride and pseudothiohydantoic acid into pseudothiohydantoin hydrochloride and pseudothiohydantoin, respectively, was proposed.</p>

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Reaction of Thiourea with Monochloroacetic Acid in Water: Revision and Probable Mechanisms

  • V. V. Andreeva,
  • D. A. Smirnova,
  • S. M. Ramsh

摘要

Abstract

The interaction of thiourea and monochloroacetic acid in water was studied, including prolonged holding of the reaction mixture at ordinary laboratory temperature. Based on the results obtained, taking into account literature data, a scheme of the reaction transformations and probable mechanisms of cyclization of the intermediate pseudothiohygantoic acid hydrochloride and pseudothiohydantoic acid into pseudothiohydantoin hydrochloride and pseudothiohydantoin, respectively, was proposed.