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Abstract <p>A convenient, sustainable, and effective protocol has been designed to synthesize biologically active bis(indolyl)methane derivatives using Ag@V<sub>2</sub>O<sub>5</sub> metal nanocomposite as a catalyst. The synthesis proceeds through the electrophilic substitution reaction of indole with aromatic aldehydes in an ethanol–water solvent system, at an ambient reaction condition. The current methodology shows remarkable advantages such as simple methodology, clean reaction, quicker reaction time, high yields, and an easy work-up and purification process. Additionally, we noticed that the catalyst showed excellent antimicrobial activity and was reused several times without significant loss of catalytic activity.</p>

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Ag@V2O5 Metal Nanocomposite: A Versatile Platform for Synthesis of Biologically Active Bis(indolyl)methane Scaffolds

  • 期刊论文

  • 发表日期：

    2025年11月1日

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  • A. Kadam,
  • N. Pandit,
  • S. Deshmukh,
  • V. Ghanwat,
  • A. Naik,
  • A. Suravase,
  • C. Bagade,
  • S. Kamble

摘要

Abstract

A convenient, sustainable, and effective protocol has been designed to synthesize biologically active bis(indolyl)methane derivatives using Ag@V2O5 metal nanocomposite as a catalyst. The synthesis proceeds through the electrophilic substitution reaction of indole with aromatic aldehydes in an ethanol–water solvent system, at an ambient reaction condition. The current methodology shows remarkable advantages such as simple methodology, clean reaction, quicker reaction time, high yields, and an easy work-up and purification process. Additionally, we noticed that the catalyst showed excellent antimicrobial activity and was reused several times without significant loss of catalytic activity.