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Abstract <p>A method was proposed for the synthesis hybrid molecules combining fragments of pyrrolidine, taurine, amino acids or 1-phenylethan-1-amine. The method is based on the reaction of 2-aryl-1-(vinylsulfonyl)pyrrolidines with amino acids or their esters by boiling in acetonitrile in the presence of triethylamine for 2 days. The structure of the obtained compounds was proven by <sup>1</sup>H, <sup>13</sup>C NMR and single crystal X-ray diffraction analysis methods.</p>

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Synthesis of New Taurine Derivatives by Reaction of 2-Aryl-1-(vinylsulfonyl)pyrrolidines with Optically Pure Amines

  • 期刊论文

  • 发表日期：

    2025年7月1日

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  • S. M. Nakypova,
  • A. V. Smolobochkin,
  • A. S. Gazizov,
  • D. P. Gerasimova,
  • N. I. Akylbekov,
  • A. R. Burilov

摘要

Abstract

A method was proposed for the synthesis hybrid molecules combining fragments of pyrrolidine, taurine, amino acids or 1-phenylethan-1-amine. The method is based on the reaction of 2-aryl-1-(vinylsulfonyl)pyrrolidines with amino acids or their esters by boiling in acetonitrile in the presence of triethylamine for 2 days. The structure of the obtained compounds was proven by 1H, 13C NMR and single crystal X-ray diffraction analysis methods.