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Abstract <p>The reaction of 3-aminothieno[2,3-<i>b</i>]pyridin-2-carboxamides with acetone in the presence of catalytic amounts of TsOH under reflux afforded a series of new 2,2-dimethyl-2,3-dihydropyrido[3′,2′:4,5]thieno[3,2-<i>d</i>]pyrimidin-4(1<i>H</i>)-ones in 88–95% yields. Possible protein targets for the new compounds were identified by molecular docking studies. 2,2-Dimethyl-3-(2-methylphenyl)-9-(4-methoxyphenyl)-7-phenyl-2,3-dihydropyrido[3′,2′:4,5]thieno[3,2-<i>d</i>]pyrimidin-4(1<i>H</i>)-one exhibits antidote effect against 2,4-dichlorophenoxyacetic acid in a laboratory experiment.</p>

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Synthesis of 2,2-Dimethyl-2,3-dihydropyrido[3′,2′:4,5]-thieno[3,2-d]pyrimidin-4(1H)-ones by Reaction of 3-Aminothieno[2,3-b]pyridine-2-carboxamides with Acetone

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  • 发表日期：

    2025年5月21日

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  • V. V. Dotsenko,
  • S. V. Rudenko,
  • D. Yu. Lukina,
  • A. K. Smirnova,
  • S. G. Krivokolysko,
  • A. Z. Temerdashev,
  • A. S. Harutyunyan,
  • E. G. Paronikyan,
  • N. A. Aksenov,
  • I. V. Aksenova

摘要

Abstract

The reaction of 3-aminothieno[2,3-b]pyridin-2-carboxamides with acetone in the presence of catalytic amounts of TsOH under reflux afforded a series of new 2,2-dimethyl-2,3-dihydropyrido[3′,2′:4,5]thieno[3,2-d]pyrimidin-4(1H)-ones in 88–95% yields. Possible protein targets for the new compounds were identified by molecular docking studies. 2,2-Dimethyl-3-(2-methylphenyl)-9-(4-methoxyphenyl)-7-phenyl-2,3-dihydropyrido[3′,2′:4,5]thieno[3,2-d]pyrimidin-4(1H)-one exhibits antidote effect against 2,4-dichlorophenoxyacetic acid in a laboratory experiment.