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Abstract <p>A diverse array of novel 2-aryl-3-amidyl-1,3-benzoxazine compounds were synthesized in 54–93% yields by La(OTf)<sub>3</sub>-catalyzed reactions of 2-[(2-hydroxybenzyl)amino]acetamides with aldehydes. The structures of the prepared compounds were characterized by IR, <sup>1</sup>H, <sup>13</sup>C NMR and HRMS methods. The antifungal activities of the compounds against plant fungi were evaluated, demonstrating the highest activity of 85.0% against <i>P</i>. <i>capsici</i> by 2-(2-nitrophenyl)-3-[(phenylcarbamoyl)methyl]-1,3-benzoxazine.</p>

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Efficient Synthesis and Antifungal Activities of Novel 2-Aryl-3-amidyl-1,3-benzoxazine Derivatives

  • 期刊论文

  • 发表日期：

    2025年8月1日

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  • Zilong Tang,
  • Guanyu Wang,
  • Xinxing Li,
  • Yichao Wan,
  • Lifen Peng

摘要

Abstract

A diverse array of novel 2-aryl-3-amidyl-1,3-benzoxazine compounds were synthesized in 54–93% yields by La(OTf)3-catalyzed reactions of 2-[(2-hydroxybenzyl)amino]acetamides with aldehydes. The structures of the prepared compounds were characterized by IR, 1H, 13C NMR and HRMS methods. The antifungal activities of the compounds against plant fungi were evaluated, demonstrating the highest activity of 85.0% against P. capsici by 2-(2-nitrophenyl)-3-[(phenylcarbamoyl)methyl]-1,3-benzoxazine.