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Abstract <p>Condensation of 1-(4-alkoxyphenyl)ethanones with aromatic aldehydes in the presence of sodium hydroxide in an aqueous-ethanol solution yielded (2<i>E</i>)-3-aryl-1-(4-alkoxyphenyl)prop-2-en-1-ones. The reaction of benzamidine and 4-methylbenzamidine hydrochlorides with the substituted chalcones in а KOH–ethanol system leads to 2,4-diaryl-6-(4-alkoxyphenyl)pyrimidines. The antimonoamine oxidase, anticonvulsant and psychotropic properties of the resulting systems were studied.</p>

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Search for Monoamine Oxidase Inhibitors among 4-Aryl-6-(4-alkoxyphenyl)-2-arylpyrimidines. Study of Anticonvulsant and Psychotropic Activities

  • 期刊论文

  • 发表日期：

    2025年4月25日

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  • N. Z. Hakobyan,
  • M. S. Safaryan,
  • A. S. Grigoryan,
  • Zh. R. Alaverdyan,
  • R. G. Paronikyan,
  • L. S. Mirzoyan,
  • H. V. Gasparyan,
  • Н. A. Panosyan,
  • A. A. Harutyunyan

摘要

Abstract

Condensation of 1-(4-alkoxyphenyl)ethanones with aromatic aldehydes in the presence of sodium hydroxide in an aqueous-ethanol solution yielded (2E)-3-aryl-1-(4-alkoxyphenyl)prop-2-en-1-ones. The reaction of benzamidine and 4-methylbenzamidine hydrochlorides with the substituted chalcones in а KOH–ethanol system leads to 2,4-diaryl-6-(4-alkoxyphenyl)pyrimidines. The antimonoamine oxidase, anticonvulsant and psychotropic properties of the resulting systems were studied.