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Abstract <p>A new series of 1,2,3-triazole tethered 2-styrylchromone derivatives were synthesized by adopting a simple and efficient regioselective Cu(I) catalyzed 1,3-dipolar cycloaddition reaction of corresponding 3-<i>O</i>-propargyl 2-styrylchromone with various aryl azides. The synthesized compounds were characterized using <sup>1</sup>H, <sup>13</sup>C NMR, HRMS and mass spectrometry and were screened for their antibacterial activity. Two representatives of synthesized dihalogen-substituted compounds showed good activity.</p>

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Synthesis and Antibacterial Activity of Novel 1,2,3-Triazole Pendant 2-Styrylchromone Derivatives

  • 期刊论文

  • 发表日期：

    2025年4月25日

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  • P. Limbadri,
  • Y. Hemasri,
  • Y. Jayaprakash Rao

摘要

Abstract

A new series of 1,2,3-triazole tethered 2-styrylchromone derivatives were synthesized by adopting a simple and efficient regioselective Cu(I) catalyzed 1,3-dipolar cycloaddition reaction of corresponding 3-O-propargyl 2-styrylchromone with various aryl azides. The synthesized compounds were characterized using 1H, 13C NMR, HRMS and mass spectrometry and were screened for their antibacterial activity. Two representatives of synthesized dihalogen-substituted compounds showed good activity.