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Abstract <p>A method was proposed for the synthesis of new biologically active compounds based on substituted 3-thienylimino-3<i>H</i>-furan-2-ones with various hydrazines and hydrazides. Synthesis in the presence of one equivalent of hydrazine or hydrazide or their excess was considered. The obtained compounds were found to possess pronounced antimicrobial activity against strains of <i>Candida albicans</i> NCTC 885-653, <i>Staphylococcus aureus</i> ATCC 6538-P, and <i>Escherichia coli</i> ATCC 25922. The acute toxicity (LD<sub>50</sub>) of the obtained compounds is &gt;1500 mg/kg and they belong to practically nontoxic compounds.</p>

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Synthesis and Study of Antimicrobial Activity of Reaction Products of Substituted 3-Thienylimino-3H-furan-2-ones with Substituted Hydrazines and Hydrazides

  • 期刊论文

  • 发表日期：

    2025年2月1日

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  • D. V. Lipin,
  • N. A. Pulina,
  • V. V. Novikova,
  • R. R. Makhmudov,
  • N. V. Zhekina,
  • V. M. Shadrin

摘要

Abstract

A method was proposed for the synthesis of new biologically active compounds based on substituted 3-thienylimino-3H-furan-2-ones with various hydrazines and hydrazides. Synthesis in the presence of one equivalent of hydrazine or hydrazide or their excess was considered. The obtained compounds were found to possess pronounced antimicrobial activity against strains of Candida albicans NCTC 885-653, Staphylococcus aureus ATCC 6538-P, and Escherichia coli ATCC 25922. The acute toxicity (LD50) of the obtained compounds is >1500 mg/kg and they belong to practically nontoxic compounds.