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Abstract <p>Complexes [Cu<sub>2</sub>(ind)<sub>4</sub>(EtOH)<sub>2</sub>] (<b>I</b>), [Cu(ind)<sub>2</sub>bpy]·1.15MeCN·0.85MeOH (<b>II</b>), and [Cu(ind)(phen)<sub>2</sub>]<sup>+</sup> ·ind<sup>–</sup>·0.5Hind·1.5H<sub>2</sub>O (<b>III</b>) were synthesized using slow diffusion of the starting solutions of copper(II) acetate, indole-2-carboxylic acid (Hind), and oligopyridines (2,2'-bipyridine (bpy)/1,10-phenanthroline (phen)). The structures of the complexes were established by single crystal X-ray diffraction and the phase purity was confirmed by powder X-ray diffraction. According to single-crystal X-ray diffraction data, <b>I</b> and <b>II</b> are molecular complexes, while <b>III</b> is an ionic complex comprising the cationic mononuclear [Cu(ind)(phen)<sub>2</sub>]<sup>+</sup> moiety in the independent part of the unit cell and the ind<sup>–</sup> anion in the outer sphere. The coordination environment of copper(II) cation (C.N.<sub>Cu</sub> 5) is described by a square pyramid (<b>I</b>, <b>III</b>) or a planar square with C.N.<sub>Cu</sub> 4 (<b>II</b>). The supramolecular level involves both hydrogen bonds and non-covalent interactions, mainly of the π…π and C–H…π type. The stability of salt solutions of <b>I</b>–<b>III</b> was studied by spectrophotometry in comparison with the free ligands and over a period of 2 days. Complexes <b>I</b>–<b>III</b> were investigated for biological activity: the antimycobacterial activity was evaluated against the non-pathogenic <i>Mycolicibacterium smegmatis</i> strain and the cytotoxicity of <b>III</b> was assessed against the test human ovarian adenocarcinoma cells (SKOV3).</p>

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First Copper(II) Indole Carboxylate Complexes: Features of Synthesis, Structural Organization, and Biological Activity

  • 期刊论文

  • 发表日期：

    2025年12月1日

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  • K. A. Koshenskova,
  • L. S. Razvorotneva,
  • A. D. Filippova,
  • F. M. Dolgushin,
  • N. V. Gogoleva,
  • O. B. Bekker,
  • V. O. Shender,
  • I. L. Eremenko,
  • I. A. Lutsenko

摘要

Abstract

Complexes [Cu2(ind)4(EtOH)2] (I), [Cu(ind)2bpy]·1.15MeCN·0.85MeOH (II), and [Cu(ind)(phen)2]+ ·ind–·0.5Hind·1.5H2O (III) were synthesized using slow diffusion of the starting solutions of copper(II) acetate, indole-2-carboxylic acid (Hind), and oligopyridines (2,2'-bipyridine (bpy)/1,10-phenanthroline (phen)). The structures of the complexes were established by single crystal X-ray diffraction and the phase purity was confirmed by powder X-ray diffraction. According to single-crystal X-ray diffraction data, I and II are molecular complexes, while III is an ionic complex comprising the cationic mononuclear [Cu(ind)(phen)2]+ moiety in the independent part of the unit cell and the ind– anion in the outer sphere. The coordination environment of copper(II) cation (C.N.Cu 5) is described by a square pyramid (I, III) or a planar square with C.N.Cu 4 (II). The supramolecular level involves both hydrogen bonds and non-covalent interactions, mainly of the π…π and C–H…π type. The stability of salt solutions of I–III was studied by spectrophotometry in comparison with the free ligands and over a period of 2 days. Complexes I–III were investigated for biological activity: the antimycobacterial activity was evaluated against the non-pathogenic Mycolicibacterium smegmatis strain and the cytotoxicity of III was assessed against the test human ovarian adenocarcinoma cells (SKOV3).