Scholarlink

Abstract <p>This study investigates α‑ketoamines from α‑diketones and arylamines using palladium and rhodium catalyst with chiral ligands. Among the catalysts tested, Pd(Tfa)<sub>2</sub>/Dppf and Rh(Acac)(CO)<sub>2</sub>/BINAP proved to be effective in facilitating the synthesis of α‑ketoamines. While high chemoselectivity and good yields were obtained, low enantioselectivity was observed, which may be attributed to the presence of multiple rhodium hydride species identified by NMR analysis. These findings highlight the chemoselectivity of this reaction, enabling the continuous production of high‑value products and synthetic intermediates.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Chemoselective Synthesis of α-Ketoamines from α-Diketones and Arylamines Using Palladium and Rhodium Catalyst

  • 期刊论文

  • 发表日期：

    2025年8月1日

查看全文
  • G. Eliad Benítez‑Medina,
  • C. P. Villamizar C.,
  • B. Anzaldo,
  • G. Hernández Téllez,
  • R. Gutierrez,
  • P. Sharma

摘要

Abstract

This study investigates α‑ketoamines from α‑diketones and arylamines using palladium and rhodium catalyst with chiral ligands. Among the catalysts tested, Pd(Tfa)2/Dppf and Rh(Acac)(CO)2/BINAP proved to be effective in facilitating the synthesis of α‑ketoamines. While high chemoselectivity and good yields were obtained, low enantioselectivity was observed, which may be attributed to the presence of multiple rhodium hydride species identified by NMR analysis. These findings highlight the chemoselectivity of this reaction, enabling the continuous production of high‑value products and synthetic intermediates.