Abstract <p>A theoretical evaluation of the activity of the medical radioisotope ⁶⁸Ga produced by cyclotron irradiation of zinc targets via the ⁶⁸Zn(<i>p</i>, <i>n</i>)⁶⁸Ga reaction has been performed. Using SRIM/TRIM, proton energy losses in the target material and the dependence of proton energy on target depth (thickness) were determined. Effective cross–sections σ(E) for the ⁶⁸Zn(<i>p</i>, <i>n</i>)⁶⁸Ga reaction were obtained using the TALYS 1.9 code. It was established that the optimal proton energy range (12.5–4.6 MeV) provides a high theoretical product yield while minimizing side reactions. For irradiation of natural and enriched zinc targets, the calculated theoretical yields were 0.82 and 4.36 GBq/(μA h), respectively, which agree with literature data. The results obtained can be used to optimize the technical parameters for the production of ⁶⁸Ga for medical applications.</p>