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Abstract <p>The methods of Circular Dichroism and UV/Vis spectrophotometry were used to study the influence of two cationic porphyrins meso-tetra-(4N-oxyethylpyridyl) porphyrin (TOEPyP4) and its Zn-containing derivative (ZnTOEPyP4) on the G-quadruplex conformation of d[5'-A(GGGTTA)<sub>3</sub>GGG-3'] sequence of human telomeric DNA. The analysis of the results indicates a single binding site for these porphyrins, but it differs depending on the porphyrin. It is assumed that TOEPyP4 binds parallel to the quartet plane on the outer surface of the G-quadruplex (external π-π stacking), and the binding of ZnTOEPyP4 also occurs externally, but in the groove of the lateral surface of the G-quadruplex (groove binding).</p>

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The Interaction of TOEPyP4 and ZnTOEPyP4 Porphyrins with G-Quadruplexes

  • 期刊论文

  • 发表日期：

    2025年3月1日

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  • I. V. Vardanyan,
  • M. Kh. Badalyan,
  • Ts. M. Jomardyan,
  • Y. B. Dalyan,
  • S. G. Haroutiunian

摘要

Abstract

The methods of Circular Dichroism and UV/Vis spectrophotometry were used to study the influence of two cationic porphyrins meso-tetra-(4N-oxyethylpyridyl) porphyrin (TOEPyP4) and its Zn-containing derivative (ZnTOEPyP4) on the G-quadruplex conformation of d[5'-A(GGGTTA)3GGG-3'] sequence of human telomeric DNA. The analysis of the results indicates a single binding site for these porphyrins, but it differs depending on the porphyrin. It is assumed that TOEPyP4 binds parallel to the quartet plane on the outer surface of the G-quadruplex (external π-π stacking), and the binding of ZnTOEPyP4 also occurs externally, but in the groove of the lateral surface of the G-quadruplex (groove binding).