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Abstract <p>A study of the fluorescent properties of MB complexes with ss-poly(dA), poly(rU), poly(rA), and poly(dT), as well as hybrid ds-structures poly(rA)-poly(dT) and poly(dA)-poly(rU), was carried out. Based on changes in fluorescence and absorption spectra, it was revealed that this ligand exhibits unequal affinity for homopolynucleotide sequences. Particularly, it was found that MS binds to poly(rA) with pronounced specificity, compared to ss-poly(dA), poly(rU), and poly(dT). The difference was also obtained for the interaction of MB with hybrid ds-polynucleotides poly(rA)-poly(dT) and poly(dA)-poly(rU).</p>

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Study of Fluorescent Properties of Methylene Blue Complexes with Ribo- and Deoxyribo-Polynucleotides

  • 期刊论文

  • 发表日期：

    2025年3月1日

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  • A. P. Antonyan,
  • M. A. Parsadanyan,
  • A. H. Karapetyan,
  • P. O. Vardevanyan

摘要

Abstract

A study of the fluorescent properties of MB complexes with ss-poly(dA), poly(rU), poly(rA), and poly(dT), as well as hybrid ds-structures poly(rA)-poly(dT) and poly(dA)-poly(rU), was carried out. Based on changes in fluorescence and absorption spectra, it was revealed that this ligand exhibits unequal affinity for homopolynucleotide sequences. Particularly, it was found that MS binds to poly(rA) with pronounced specificity, compared to ss-poly(dA), poly(rU), and poly(dT). The difference was also obtained for the interaction of MB with hybrid ds-polynucleotides poly(rA)-poly(dT) and poly(dA)-poly(rU).