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Abstract <p>As demonstrated by the example of serotonin, 3-(<i>N</i>-pyrrolyl)propanoyl-L-histidine, sodium <i>p</i>-phenylbenzoate, and Pro–Gly–Pro, activation of the isotope exchange with D<sub>2</sub>O also occurred when a solution of an organic compound in D<sub>2</sub>O was mixed with 5% Pd/Al<sub>2</sub>O<sub>3</sub> or 5% Pd/С (after preliminary treatment of catalysts with deuterium gas on heating). When implementing this technique, 2–3 atoms of deuterium were incorporated in serotonin, 4–5 atoms, in Pro–Gly–Pro, 7–8 atoms, in 3-(<i>N</i>-pyrrolyl)propanoyl-L-histidine, and 3–4 atoms, in sodium <i>p</i>-phenylbenzoate. In the latter case, as judged from the composition of the reaction products, atomic deuterium takes part in the activation of isotope exchange with D<sub>2</sub>O. The participation of atomic deuterium in these reactions follows from the intensification of the degradation of the compounds during deuteration. When using compounds that do not contain labile fragments, isotope exchange with D<sub>2</sub>O can be activated by keeping the catalyst at room temperature and heating.</p>

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Effect of Temperature during Preactivation of 5% Pd/C and 5% Pd/Al2O3 with Deuterium Gas on the Isotope Exchange between Deuterium Water and an Organic Compound

  • 期刊论文

  • 发表日期：

    2025年2月1日

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  • V. P. Shevchenko,
  • I. Yu. Nagaev,
  • K. V. Shevchenko,
  • L. A. Andreeva,
  • N. F. Myasoedov

摘要

Abstract

As demonstrated by the example of serotonin, 3-(N-pyrrolyl)propanoyl-L-histidine, sodium p-phenylbenzoate, and Pro–Gly–Pro, activation of the isotope exchange with D2O also occurred when a solution of an organic compound in D2O was mixed with 5% Pd/Al2O3 or 5% Pd/С (after preliminary treatment of catalysts with deuterium gas on heating). When implementing this technique, 2–3 atoms of deuterium were incorporated in serotonin, 4–5 atoms, in Pro–Gly–Pro, 7–8 atoms, in 3-(N-pyrrolyl)propanoyl-L-histidine, and 3–4 atoms, in sodium p-phenylbenzoate. In the latter case, as judged from the composition of the reaction products, atomic deuterium takes part in the activation of isotope exchange with D2O. The participation of atomic deuterium in these reactions follows from the intensification of the degradation of the compounds during deuteration. When using compounds that do not contain labile fragments, isotope exchange with D2O can be activated by keeping the catalyst at room temperature and heating.