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Abstract <p>The development of new magnetic nanoparticles (MNP)-polymer systems with enhanced targeted cancer therapy has been made possible by new advancements in nanotechnology. Biocompatible polymers show a unique magnetic property and tunability enable it more precise for drug delivery, leading to improved therapeutic outcomes with less negative side effects. External magnetic fields can control magnetic nanoparticles, enabling their delivery to specific tumor sites. The designed polymeric nanocomposite has responded to viscosity, pH, temperature, or enzyme activity, enabling the local and controlled release of chemotherapeutic agents in the tumor microenvironment. This review focuses on the design concepts and principles, preparation methods, and functionalization of MNP-polymer systems for possible uses in cancer therapy. Also, it addresses critical challenges such as biocompatibility, stability, and the regulatory issues that limit clinical applicability. Such innovative developments in the new systems present a clearer perspective on redesigning the facets of cancer treatment.</p>

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Smart Magnetic Nanoparticle-Polymer Systems for Targeted Cancer Therapy: a Review

  • 期刊论文

  • 发表日期：

    2025年7月14日

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  • G. Sanjay,
  • K. Radhakrishnan,
  • A. Dinesh,
  • V. Mohanavel,
  • Manikandan Ayyar,
  • Rajendra P. Patil,
  • Madhappan Santhamoorthy,
  • Saravana Kumar Jaganathan,
  • S. Santhoshkumar,
  • Anish Khan,
  • Pijush Kanti Mondal,
  • Malik Abdul Rub,
  • Naved Azum

摘要

Abstract

The development of new magnetic nanoparticles (MNP)-polymer systems with enhanced targeted cancer therapy has been made possible by new advancements in nanotechnology. Biocompatible polymers show a unique magnetic property and tunability enable it more precise for drug delivery, leading to improved therapeutic outcomes with less negative side effects. External magnetic fields can control magnetic nanoparticles, enabling their delivery to specific tumor sites. The designed polymeric nanocomposite has responded to viscosity, pH, temperature, or enzyme activity, enabling the local and controlled release of chemotherapeutic agents in the tumor microenvironment. This review focuses on the design concepts and principles, preparation methods, and functionalization of MNP-polymer systems for possible uses in cancer therapy. Also, it addresses critical challenges such as biocompatibility, stability, and the regulatory issues that limit clinical applicability. Such innovative developments in the new systems present a clearer perspective on redesigning the facets of cancer treatment.