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Abstract <p>Low-temperature atmospheric-pressure plasma jets, which generate a broad spectrum of reactive oxygen species and produce periodic action of electric fields are a promising tool that can be used in plasma medicine. When a cold atmosphericplasma jet (CAPJ) is applied to cancerous tumors, determining the correct dosage is crucial for optimal treatment results with minimal side effects. In this study, to optimize the CAPJ characteristics, the configuration of the electric field in the streamer propagation zone between the nozzle and the target was modified using an additional ring electrode. It was shown that the magnitude and location of maximum discharge current can be controlled, which increases the efficiency and safety of using CAPJs in medical applications. A study was conducted of the screening properties of a hydrogel applied to the skin of tumor-bearing animals during CAPJ treatment. Studies of the combined effect of gold nanoparticles and CAPJs were continued, and results showing an effective deceleration of tumor growth rates in animals after a single CAPJ treatment combined with gold nanoparticles carrying antibodies to the TYRP1 protein, which is expressed by melanomas of different types, were obtained.</p>

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Methods of Enhancing the Anti-Cancer Effect during the Simultaneous Processing of Cells by a Cold Atmospheric Plasma Jet and Gold Nanoparticles

  • 期刊论文

  • 发表日期：

    2025年8月1日

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  • I. Schweigert,
  • D. Zakrevsky,
  • E. Milakhina,
  • P. Guguin,
  • M. Biryukov,
  • A. Polyakova,
  • E. Gorbunova,
  • A. Epanchintseva,
  • I. Pyshnaya,
  • O. Koval

摘要

Abstract

Low-temperature atmospheric-pressure plasma jets, which generate a broad spectrum of reactive oxygen species and produce periodic action of electric fields are a promising tool that can be used in plasma medicine. When a cold atmosphericplasma jet (CAPJ) is applied to cancerous tumors, determining the correct dosage is crucial for optimal treatment results with minimal side effects. In this study, to optimize the CAPJ characteristics, the configuration of the electric field in the streamer propagation zone between the nozzle and the target was modified using an additional ring electrode. It was shown that the magnitude and location of maximum discharge current can be controlled, which increases the efficiency and safety of using CAPJs in medical applications. A study was conducted of the screening properties of a hydrogel applied to the skin of tumor-bearing animals during CAPJ treatment. Studies of the combined effect of gold nanoparticles and CAPJs were continued, and results showing an effective deceleration of tumor growth rates in animals after a single CAPJ treatment combined with gold nanoparticles carrying antibodies to the TYRP1 protein, which is expressed by melanomas of different types, were obtained.