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Abstract <p>We presented the development and validation of an experimental setup for conducting preclinical proton FLASH research on small animal models. A dedicated system for Wistar rats with intracerebral glioma 101.8 was developed. Its configuration was optimized using Monte Carlo simulations (TOPAS/Geant4) and includes custom-designed devices for passive beam scattering, collimation, animal immobilization, and imaging-based positioning. The implemented methodology ensures precise and reproducible dose delivery at both conventional and ultra-high dose rates (FLASH). The described experimental complex provides a basis for future radiobiological studies on the FLASH effect.</p>

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Experiments to Study the FLASH Effect in Proton Irradiation of Laboratory Animals

  • 期刊论文

  • 发表日期：

    2026年6月18日

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  • S. V. Akulinichev,
  • Yu. K. Gavrilov,
  • D. A. Kokontsev,
  • V. V. Kudelkina,
  • V. V. Martynova,
  • G. V. Merzlikin,
  • D. G. Tagabilev,
  • I. A. Yakovlev

摘要

Abstract

We presented the development and validation of an experimental setup for conducting preclinical proton FLASH research on small animal models. A dedicated system for Wistar rats with intracerebral glioma 101.8 was developed. Its configuration was optimized using Monte Carlo simulations (TOPAS/Geant4) and includes custom-designed devices for passive beam scattering, collimation, animal immobilization, and imaging-based positioning. The implemented methodology ensures precise and reproducible dose delivery at both conventional and ultra-high dose rates (FLASH). The described experimental complex provides a basis for future radiobiological studies on the FLASH effect.