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Abstract <p>Marine red algae, particularly <i>Acanthophora spicifera</i>, have emerged as valuable sources of bioactive compounds with diverse biological applications. This study aims to comprehensively analyze the phytochemical composition, antibacterial efficacy, and In-vitro biological activities of <i>Acanthophora spicifera</i>. Characterization was performed using a suite of analytical techniques, including UV spectrophotometry, scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR), gas chromatography-mass spectrometry (GC-MS). Antibacterial activity was assessed against Gram-positive (<i>Staphylococcus aureus,</i> <i>Bacillus subtilis</i>) and Gram-negative (<i>Escherichia coli,</i> <i>Pseudomonas aeruginosa</i>) bacteria, demonstrating significant inhibitory effects, with zones of inhibition correlating to phytochemical potency. In vitro biological assays, scratch assay using the 3T3 fibroblast cell line, highlighted the cytotoxic and wound-healing potential of <i>Acanthophora spicifera</i>. while the scratch assay indicated enhanced cell migration, suggesting potential applications in wound healing.</p>

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Phytochemical Characterization, Antibacterial Efficacy, and In-vitro Biological Activities of Acanthophora spicifera

  • 期刊论文

  • 发表日期：

    2025年9月5日

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  • Saranya Sivakumar,
  • Raghavendra Ramalingam,
  • Subhashini Swaminathan

摘要

Abstract

Marine red algae, particularly Acanthophora spicifera, have emerged as valuable sources of bioactive compounds with diverse biological applications. This study aims to comprehensively analyze the phytochemical composition, antibacterial efficacy, and In-vitro biological activities of Acanthophora spicifera. Characterization was performed using a suite of analytical techniques, including UV spectrophotometry, scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR), gas chromatography-mass spectrometry (GC-MS). Antibacterial activity was assessed against Gram-positive (Staphylococcus aureus, Bacillus subtilis) and Gram-negative (Escherichia coli, Pseudomonas aeruginosa) bacteria, demonstrating significant inhibitory effects, with zones of inhibition correlating to phytochemical potency. In vitro biological assays, scratch assay using the 3T3 fibroblast cell line, highlighted the cytotoxic and wound-healing potential of Acanthophora spicifera. while the scratch assay indicated enhanced cell migration, suggesting potential applications in wound healing.