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Abstract <p>In this study, the metal−organic framework (<b>MOF</b>) material MOF-801 was synthesized and further derivatized to introduce C=C double bonds on its surface. Then, a MOF-801/polymer monolithic column was prepared using derivatized MOF-801, lauryl methacrylate and methacrylic acid as comonomers, ethylene glycol dimethacrylate as a cross-linker, <i>n</i>-hexanol as a porogen, and azobisisobutyronitrile as an initiator. After being characterized, the monolithic material was employed as a solid-phase extraction adsorbent to perform online enrichment and purification of vitexicarpin in <i>Vitex trifolia</i>, which was coupled with high-performance liquid chromatography. The enrichment factor reached up to 212.5. Under this condition, the content of vitexicarpin in the eluate was 60.63%, which was much higher than that in <i>Vitex trifolia</i> (0.03%). This method demonstrated excellent linearity within the range of 0.13 µg/mL to 5 × 10<sup>2</sup> µg/mL with a calibration equation of <i>y</i> = 0.63135<i>x</i> + 0.70981, and the correlation coefficient was 0.9992. The inter-day and intra-day precision was less than 1.63%. The recovery rate of vitexicarpin in <i>Vitex trifolia</i> was between 95 and 105%.</p>

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Fabrication of Hybrid Monoliths Integrating a Metal–Organic Framework for Online Enrichment and Determination of Vitexicarpin in Vitex trifolia

  • 期刊论文

  • 发表日期：

    2026年5月31日

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  • Ping Liu,
  • Shuo Yuan,
  • Haiyan Liu

摘要

Abstract

In this study, the metal−organic framework (MOF) material MOF-801 was synthesized and further derivatized to introduce C=C double bonds on its surface. Then, a MOF-801/polymer monolithic column was prepared using derivatized MOF-801, lauryl methacrylate and methacrylic acid as comonomers, ethylene glycol dimethacrylate as a cross-linker, n-hexanol as a porogen, and azobisisobutyronitrile as an initiator. After being characterized, the monolithic material was employed as a solid-phase extraction adsorbent to perform online enrichment and purification of vitexicarpin in Vitex trifolia, which was coupled with high-performance liquid chromatography. The enrichment factor reached up to 212.5. Under this condition, the content of vitexicarpin in the eluate was 60.63%, which was much higher than that in Vitex trifolia (0.03%). This method demonstrated excellent linearity within the range of 0.13 µg/mL to 5 × 102 µg/mL with a calibration equation of y = 0.63135x + 0.70981, and the correlation coefficient was 0.9992. The inter-day and intra-day precision was less than 1.63%. The recovery rate of vitexicarpin in Vitex trifolia was between 95 and 105%.