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Abstract <p>Bisphenol A (BPA) is widely used as a hardener in the plastics industry. However, its release and circulation in ecosystems lead to contamination of drinking water, which negatively impacts the human endocrine system. Therefore, there is a need for simple and efficient tools for monitoring BPA. This study presents a combination of two approaches for this purpose: the use of magnetic particles (MP) as antibody carriers and immunochromatographic test strips for detecting labeled immune complexes. The visual limit of detection (LOD) of BPA was 10 μg/mL, the instrumental LOD was 55 ng/mL, and the working range of detectable concentrations was 0.1–10 μg/mL. The efficacy of using the MP conjugate for analyte concentration was demonstrated, resulting in an approximately 200-fold reduction of the LOD. The developed immunochromatographic assay (ICA) is suitable for the qualitative monitoring and quantitative determination of BPA in drinking and natural water samples (with 94–106% recoveries).</p>

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Immunochromatographic Test System for the Determination of Bisphenol A with Magnetic Concentration

  • 期刊论文

  • 发表日期：

    2025年12月15日

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  • N. A. Taranova,
  • A. A. Bulanaya,
  • A. V. Zherdev,
  • B. B. Dzantiev

摘要

Abstract

Bisphenol A (BPA) is widely used as a hardener in the plastics industry. However, its release and circulation in ecosystems lead to contamination of drinking water, which negatively impacts the human endocrine system. Therefore, there is a need for simple and efficient tools for monitoring BPA. This study presents a combination of two approaches for this purpose: the use of magnetic particles (MP) as antibody carriers and immunochromatographic test strips for detecting labeled immune complexes. The visual limit of detection (LOD) of BPA was 10 μg/mL, the instrumental LOD was 55 ng/mL, and the working range of detectable concentrations was 0.1–10 μg/mL. The efficacy of using the MP conjugate for analyte concentration was demonstrated, resulting in an approximately 200-fold reduction of the LOD. The developed immunochromatographic assay (ICA) is suitable for the qualitative monitoring and quantitative determination of BPA in drinking and natural water samples (with 94–106% recoveries).