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Abstract <p>Simultaneous determination of acetaminophen and uric acid in biological samples was performed using differential pulse voltammetry (<b>DPV</b>) on a glassy carbon electrode coupled with orthogonal signal correction-partial least squares (<b>OSC-PLS</b>). The optimum parameters were set at pH 8.0, a scan rate of 10 mV/s, and a pulse height of 50 mV. Both analytes showed peaks at about 390 mV. OSC-PLS was performed to solve the interference problem in the voltammograms. DPV calibration showed broad dynamic ranges of 10.0–220.0 and 10.0–210.0 µmol/L for acetaminophen and uric acid, respectively. The method was successfully applied to human plasma and urine samples without any pretreatment.</p>

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Simultaneous Determination of Acetaminophen and Uric Acid in Biological Samples Using Differential Pulse Voltammetry and Orthogonal Signal Correction-Partial Least Squares

  • 期刊论文

  • 发表日期：

    2025年11月11日

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  • Zeinab Pourghobadi,
  • Masoomeh Naseri,
  • Ali Niazi,
  • Mitra Mohammadi Ghasemi

摘要

Abstract

Simultaneous determination of acetaminophen and uric acid in biological samples was performed using differential pulse voltammetry (DPV) on a glassy carbon electrode coupled with orthogonal signal correction-partial least squares (OSC-PLS). The optimum parameters were set at pH 8.0, a scan rate of 10 mV/s, and a pulse height of 50 mV. Both analytes showed peaks at about 390 mV. OSC-PLS was performed to solve the interference problem in the voltammograms. DPV calibration showed broad dynamic ranges of 10.0–220.0 and 10.0–210.0 µmol/L for acetaminophen and uric acid, respectively. The method was successfully applied to human plasma and urine samples without any pretreatment.