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Abstract <p>In this study, a resonance Rayleigh scattering (<b>RRS</b>) technique and a spectrofluorimetric method were developed using a PbS quantum dot–glutathione nanocomposite sensor for the detection of 6-mercaptopurine in real samples. The sensor was characterized using Fourier transform infrared spectroscopy, X-ray diffraction, scanning electron microscopy, and transmission electron microscopy. The scattering intensity (∆<i>I</i><sub>RRS</sub>) signal was detected using a fluorescence detector at an excitation wavelength of 345 nm. The analytical performance of the coupled system demonstrated a linear response to 6-mercaptopurine over a concentration range of 0.05–200.0 ng/mL. The method exhibited a relative standard deviation of ±1.1% and a detection limit (3 s/m) of 0.05 ng/mL, with a response time of 60 s in a Britton – Robinson buffer solution. Furthermore, the PbS quantum dot–glutathione nanocomposite sensor, based on the RRS technique, was successfully applied for the determination of 6-mercaptopurine in samples. The proposed method could be used for the analysis of pharmaceutical formulations, human biological fluids, and hospital samples for the detection of different drugs.</p>

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Resonance Rayleigh Scattering and Spectrofluorimetric Sensing of 6-Mercaptopurine Using PbS Quantum Dot–Glutathione Nanocomposites

  • 期刊论文

  • 发表日期：

    2025年7月25日

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  • Abdolmohsen Amouri,
  • Farzaneh Marahel,
  • Alireza Geramizadegan,
  • Mohammad Reza Asghari Ganjeh

摘要

Abstract

In this study, a resonance Rayleigh scattering (RRS) technique and a spectrofluorimetric method were developed using a PbS quantum dot–glutathione nanocomposite sensor for the detection of 6-mercaptopurine in real samples. The sensor was characterized using Fourier transform infrared spectroscopy, X-ray diffraction, scanning electron microscopy, and transmission electron microscopy. The scattering intensity (∆IRRS) signal was detected using a fluorescence detector at an excitation wavelength of 345 nm. The analytical performance of the coupled system demonstrated a linear response to 6-mercaptopurine over a concentration range of 0.05–200.0 ng/mL. The method exhibited a relative standard deviation of ±1.1% and a detection limit (3 s/m) of 0.05 ng/mL, with a response time of 60 s in a Britton – Robinson buffer solution. Furthermore, the PbS quantum dot–glutathione nanocomposite sensor, based on the RRS technique, was successfully applied for the determination of 6-mercaptopurine in samples. The proposed method could be used for the analysis of pharmaceutical formulations, human biological fluids, and hospital samples for the detection of different drugs.