Abstract <p>The present review provides a comprehensive overview of the development of analytical methodologies that are well-developed and validated for the estimation of memantine. Memantine is an N-methyl-D-aspartate receptor and is widely used for dementia, Parkinson’s disease, pervasive developmental disorders, schizophrenia, and alcohol abuse disorder. However, the estimation of memantine continues to attract researchers' attention due to its unique chemical properties. Memantine is a saturated compound belonging to biopharmaceutics classification system Class I, due to its high solubility and permeability. However, its lack of unsaturation makes direct detection using ultraviolet-visible (<b>UV-Vis</b>) spectroscopy challenging. Consequently, various analytical approaches have been developed and validated for the detection of memantine, including UV-Vis spectroscopy, fluorescence spectroscopy, infrared spectroscopy, voltammetry, potentiometry, liquid chromatography, gas chromatography, nuclear magnetic resonance spectroscopy, and other hyphenated techniques. This paper provides comprehensive insights for analysts interested in developing analytical methods.</p>