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Abstract <p>The objective of this study is to develop a composite coating using chitosan (Chit), hydroxyapatite (HAp), and vascular endothelial growth factor-A (VEGF). The bioactive coating was created through the electrochemical deposition of chitosan onto a laser-treated titanium alloy surface, followed by the adsorption of VEGF. Our in vitro experiments have shown that this discs with laser-engraved parallel linear grooves and bioactive coating enhances the adhesion of human mesenchymal stromal cells and exhibits osteoinductive and proangiogenic properties in vitro. This combination of the VEGF-loaded composite coating and substrate microrelief will enhance osteointegration and osteosynthesis at the bone interface.</p>

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Composite Chitosan-Based Coating for the Enhancement of Osteoinductivity and Osteoconductivity of Titanium Alloys

  • 期刊论文

  • 发表日期：

    2025年12月1日

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  • K. I. Makrinskiy,
  • A. L. Klyuev,
  • N. Yu. Anisimova,
  • M. V. Kiselevskiy,
  • A. S. Gornakova,
  • O. A. Kogtenkova,
  • E. B. Kulbazkiy,
  • B. B. Straumal

摘要

Abstract

The objective of this study is to develop a composite coating using chitosan (Chit), hydroxyapatite (HAp), and vascular endothelial growth factor-A (VEGF). The bioactive coating was created through the electrochemical deposition of chitosan onto a laser-treated titanium alloy surface, followed by the adsorption of VEGF. Our in vitro experiments have shown that this discs with laser-engraved parallel linear grooves and bioactive coating enhances the adhesion of human mesenchymal stromal cells and exhibits osteoinductive and proangiogenic properties in vitro. This combination of the VEGF-loaded composite coating and substrate microrelief will enhance osteointegration and osteosynthesis at the bone interface.