Abstract <p>In this paper, we have shown that the origin of genetic and epigenetic information is connected with the origin of organisms. The Crick diagram describing the sequence hypothesis and the central dogma of molecular biology is modified so as to describe the origin of genes and regulation; epigenetic interactions and differential gene expression; and genome, transcriptome and proteome evolution. We also formulated three corresponding statements about the evolution of biological information flow after the origin of organisms that may be considered as the extension of the sequence hypothesis and the central dogma. These statements are valid during the evolution of organisms. The origin of new genetic and epigenetic information is connected with frozen accidents that accompany every step of progressive evolution.</p>