Abstract <p>In this article the role of epigenetic factors, in particular, DNA methylation, in the processes of interaction of the SARS-CoV-2 virus with the human body and in the pathogenesis of COVID-19 is considered. An overview of experimental studies on the use of microRNA to regulate the expression of genes processed during the interaction of the virus with the host body is presented. A potential new strategy in the diagnosis and therapy of COVID-19 and other viral factors using RNA interference is considered.</p>

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Epigenetic Approaches to Diagnosis and Therapy of COVID-19: Features of Differential DNA Methylation Profile as Potential Targets for Therapy by the Method of RNA Interference

  • O. B. Belopolskaya,
  • S. A. Borinskaya,
  • A. A. Rimskaya,
  • N. V. Markina,
  • N. K. Yankovsky

摘要

Abstract

In this article the role of epigenetic factors, in particular, DNA methylation, in the processes of interaction of the SARS-CoV-2 virus with the human body and in the pathogenesis of COVID-19 is considered. An overview of experimental studies on the use of microRNA to regulate the expression of genes processed during the interaction of the virus with the host body is presented. A potential new strategy in the diagnosis and therapy of COVID-19 and other viral factors using RNA interference is considered.