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Abstract <p>To date, the etiology of the clinical course of COVID-19 is not well understood. The role of many factors is assumed, including the genetic characteristics of the individual. Replicative association analysis of COVID-19 severity with the single nucleotide variant (SNV) rs73064425 of the <i>LZTFL1</i> gene was performed. The data obtained indicate the association of the single nucleotide substitution rs73064425 of the <i>LZTFL1</i> gene and the severe form of COVID-19 in the Russian population of Tomsk. Possible mechanisms of the involvement of the studied SNV in the disease pathogenetics are discussed. Variability in the <i>T</i>-allele frequencies of rs73064425 in the world populations was determined.</p>

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Association of the LZTFL1 Gene Polymorphic Marker rs73064425 with Severity of COVID-19 and the World-Wide Distribution of Its Allele Frequencies

  • 期刊论文

  • 发表日期：

    2025年9月8日

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  • R. A. Korneeva,
  • E. A. Trifonova,
  • A. V. Bocharova,
  • A. A. Gusarova,
  • A. A. Babovskaya,
  • M. M. Gavrilenko,
  • T. V. Gabidulina,
  • O. V. Zhilyakova,
  • N. A. Kolesnikov,
  • V. A. Stepanov

摘要

Abstract

To date, the etiology of the clinical course of COVID-19 is not well understood. The role of many factors is assumed, including the genetic characteristics of the individual. Replicative association analysis of COVID-19 severity with the single nucleotide variant (SNV) rs73064425 of the LZTFL1 gene was performed. The data obtained indicate the association of the single nucleotide substitution rs73064425 of the LZTFL1 gene and the severe form of COVID-19 in the Russian population of Tomsk. Possible mechanisms of the involvement of the studied SNV in the disease pathogenetics are discussed. Variability in the T-allele frequencies of rs73064425 in the world populations was determined.