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<p>The expression levels of long noncoding RNAs (lncRNAs) MALAT1, GAS5, and TUG1 in peripheral blood leukocytes (PBLs) of patients with pulmonary sarcoidosis (<i>n</i> = 30, mean age 47 ± 5.23 years) and 27 conditionally healthy donors (control group, <i>n</i> = 27, mean age 42 ± 3.65 years)) were analyzed. The expression level of lncRNAs MALAT1, GAS5, and TUG1 was determined by real-time PCR. According to the data obtained in patients with progressive pulmonary sarcoidosis (stage II of the disease), the expression level of lncRNAs MALAT1, GAS5, and TUG1 was significantly increased compared to the control group (<i>p</i>&#xa0;&lt; 0.001). Under the glucocorticosteroid (GCS) therapy, a decrease level of lncRNAs MALAT1 and TUG1 was detected, while the expression of GAS5 increased before and during GCS therapy (<i>p</i> &lt; 0.001). The observed changes in the expression level of the studied long noncoding RNAs may be associated both with the development of the inflammatory process in pulmonary sarcoidosis and with the pathogenetic mechanisms of this disease.</p>

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Expression of Long Noncoding RNAs MALAT1, GAS5, and TUG1 in Peripheral Blood Leucocytes of Pulmonary Sarcoidosis Patients before and after Glucocorticosteroid Therapy

  • 期刊论文

  • 发表日期：

    2025年8月29日

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  • I. E. Malysheva,
  • O. V. Balan,
  • E. L. Tikhonovich

摘要

The expression levels of long noncoding RNAs (lncRNAs) MALAT1, GAS5, and TUG1 in peripheral blood leukocytes (PBLs) of patients with pulmonary sarcoidosis (n = 30, mean age 47 ± 5.23 years) and 27 conditionally healthy donors (control group, n = 27, mean age 42 ± 3.65 years)) were analyzed. The expression level of lncRNAs MALAT1, GAS5, and TUG1 was determined by real-time PCR. According to the data obtained in patients with progressive pulmonary sarcoidosis (stage II of the disease), the expression level of lncRNAs MALAT1, GAS5, and TUG1 was significantly increased compared to the control group (p < 0.001). Under the glucocorticosteroid (GCS) therapy, a decrease level of lncRNAs MALAT1 and TUG1 was detected, while the expression of GAS5 increased before and during GCS therapy (p < 0.001). The observed changes in the expression level of the studied long noncoding RNAs may be associated both with the development of the inflammatory process in pulmonary sarcoidosis and with the pathogenetic mechanisms of this disease.