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Abstract <p>Breast cancer is number one in terms of indicators of mortality and morbidity in women. In the postgenomic era, it was revealed that the development of pathology is linked with specificities of gene expression including transcriptional, posttranscriptional, translational, and epigenetic regulation. In the research, biomaterial of 16 patients (8 patients with stage I/II luminal A breast cancer and 8 healthy women) was included. Functional enrichment analysis using the WebGestalt source and different databases (Gene Ontology, KEGG) showed alterations in expression of genes involved in immunological response, metabolism of carbohydrates, glutathione, and nicotinamide, DNA repair, ion transport, and intracellular signals transition. The results obtained expand our vision about specificities of the transcriptome of blood mononuclear cells during breast cancer at an early stage.</p>

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Microarray Analysis of the Transcriptome of Peripheral Blood Lymphocytes in Breast Cancer Patients

  • 期刊论文

  • 发表日期：

    2025年6月26日

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  • V. I. Minina,
  • R. A. Titov,
  • V. Yu. Buslaev,
  • R. R. Savchenko,
  • A. A. Slepcov,
  • M. L. Bakanova,
  • N. A. Gavrineva,
  • M. V. Katanakhova,
  • A. N. Glushkov

摘要

Abstract

Breast cancer is number one in terms of indicators of mortality and morbidity in women. In the postgenomic era, it was revealed that the development of pathology is linked with specificities of gene expression including transcriptional, posttranscriptional, translational, and epigenetic regulation. In the research, biomaterial of 16 patients (8 patients with stage I/II luminal A breast cancer and 8 healthy women) was included. Functional enrichment analysis using the WebGestalt source and different databases (Gene Ontology, KEGG) showed alterations in expression of genes involved in immunological response, metabolism of carbohydrates, glutathione, and nicotinamide, DNA repair, ion transport, and intracellular signals transition. The results obtained expand our vision about specificities of the transcriptome of blood mononuclear cells during breast cancer at an early stage.