Abstract <p>Lead (Pb) contaminated soils significantly affect the plant growth and ecosystems, making it an apprehension to the environment. Non-edible oilseed crop, such as castor bean (<i>Ricinus communis</i> L.), is attracting the attention of researchers for its ability to phytoremediate heavy metal contaminated soils. Hence, contemporary study intended to gauge the growth metrics, physiological indices, phytochemical profiles, and phytoremediation responses of castor bean genotypes under varying Pb levels (300, 600, and 1000 mg/kg) in pot conditions. Results indicated a decline in agro-physiological, and photosynthetic parameters in both genotypes as compared to control. Similarly, the activities of superoxide dismutase (SOD) and peroxidase declined, whereas catalase (CAT) and ascorbate peroxidase (APX) were higher in both genotypes. Regarding osmolytes, total soluble proteins (TSP) and total free amino acids (TFA) showed a decrease, while total soluble sugars (TSS) and total phenolic content (TPC) exhibited an increase in response to Pb stress. The genotypes demonstrated a significant ability to accumulate Pb in both roots and shoots, emphasizing the crucial role of castor bean in reducing Pb contamination in soil. At 1000 mg Pb/kg, the highest root uptake was observed in NIAB-2020 (63 µg/plant) followed by C-3 (50.8 µg/plant). NIAB-2020 demonstrated the higher translocation factor (TF) than C-3, while both genotypes showed non-significant difference in metal tolerance index (MTI). These outcomes propose castor bean as an encouraging entrant for the remediation of Pb contaminated soils. However, further in-situ studies are required to substantiate the verdicts of this research.</p>