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Abstract <p>A series of nonequilibrium-swollen biopolymer materials based on <i>N</i>-(1,2-dicarboxyethyl) chitosan (DCEC), <i>N</i>,<i>O</i>-(carboxymethyl) chitosan (CMC), <i>N</i>-(2-carboxyethyl) chitosan (CEC) and hyaluronic acid (HA) as carboxyl-containing polysaccharides were obtained. Evaluation of the mechanical strength of the swollen materials under compression showed that the samples of biopolymers based on <i>N</i>-(1,2-dicarboxyethyl) chitosan with a functionalization degree of 0.35, 0.5 and <i>N</i>,<i>O</i>-(carboxymethyl) chitosan with a functionalization degree of 1, were destroyed, probably due to the formation of a denser network of intermolecular interactions. Materials based on hyaluronic acid and <i>N</i>-(2-carboxyethyl) chitosan showed high elasticity and plasticity. However, the biopolymer material based on hyaluronic acid has lower mechanical strength due to its low molecular weight. A sample based on <i>N</i>-(2-carboxyethyl) chitosan with a functionalization degree of 1 is characterized by high mechanical strength and elasticity, with a true stress of 1.24 MPa. This opens the possibility of developing new medical materials based on these biopolymers.</p>

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Mechanical Properties of Nonequilibrium-Swollen Biopolymer Materials Based on Carboxyalkylated Chitosan Derivatives

  • 期刊论文

  • 发表日期：

    2025年4月1日

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  • E. A. Veretennikova,
  • E. O. Zemlyakova,
  • N. A. Drukarenko,
  • A. V. Pestov,
  • O. V. Koryakova,
  • A. V. Zhilyakov,
  • I. S. Kamantsev,
  • S. A. Chernyadyev,
  • A. V. Kuznetsov

摘要

Abstract

A series of nonequilibrium-swollen biopolymer materials based on N-(1,2-dicarboxyethyl) chitosan (DCEC), N,O-(carboxymethyl) chitosan (CMC), N-(2-carboxyethyl) chitosan (CEC) and hyaluronic acid (HA) as carboxyl-containing polysaccharides were obtained. Evaluation of the mechanical strength of the swollen materials under compression showed that the samples of biopolymers based on N-(1,2-dicarboxyethyl) chitosan with a functionalization degree of 0.35, 0.5 and N,O-(carboxymethyl) chitosan with a functionalization degree of 1, were destroyed, probably due to the formation of a denser network of intermolecular interactions. Materials based on hyaluronic acid and N-(2-carboxyethyl) chitosan showed high elasticity and plasticity. However, the biopolymer material based on hyaluronic acid has lower mechanical strength due to its low molecular weight. A sample based on N-(2-carboxyethyl) chitosan with a functionalization degree of 1 is characterized by high mechanical strength and elasticity, with a true stress of 1.24 MPa. This opens the possibility of developing new medical materials based on these biopolymers.