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Abstract <p>A polymer composite material for medical applications based on acrylic hydrogels and detonation nanodiamonds containing the medicinal substance metronidazole has been synthesized. The kinetics of gel swelling in media of different ionic strengths and pH values and the kinetics of metronidazole release from it have been studied. It has been shown that detonation nanodiamonds affect the completeness of metronidazole release. Mathematical models that best describe the process of metronidazole desorption and swelling kinetics have been proposed. The mechanical properties of the hydrogels and the frequency dependences of their dynamic moduli have been studied using oscillation rheometry methods. The effect of detonation nanodiamonds and metronidazole on the dynamic moduli, the mechanical loss tangent, and the parameters of the polymer matrix network has been shown.</p>

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Sorption and Mechanical Characteristics of a Polymer Composite Based on Acrylic Hydrogel and Detonation Nanodiamonds and the Kinetics of Metronidazole Release from It

  • 期刊论文

  • 发表日期：

    2025年2月1日

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  • D. V. Grigoriev,
  • A. V. Gudkin,
  • E. V. Sivtsov,
  • A. V. Kalinin,
  • M. V. Uspenskaya

摘要

Abstract

A polymer composite material for medical applications based on acrylic hydrogels and detonation nanodiamonds containing the medicinal substance metronidazole has been synthesized. The kinetics of gel swelling in media of different ionic strengths and pH values and the kinetics of metronidazole release from it have been studied. It has been shown that detonation nanodiamonds affect the completeness of metronidazole release. Mathematical models that best describe the process of metronidazole desorption and swelling kinetics have been proposed. The mechanical properties of the hydrogels and the frequency dependences of their dynamic moduli have been studied using oscillation rheometry methods. The effect of detonation nanodiamonds and metronidazole on the dynamic moduli, the mechanical loss tangent, and the parameters of the polymer matrix network has been shown.