Abstract <p>Microbial methanogenesis can potentially mitigate atmospheric CO₂ emissions while simultaneously establishing new methane reserves. Natural CO₂ fields demonstrate geological stability and are frequently used for enhanced oil recovery. However, anthropogenic CO₂ sequestration entails significant safety risks and operational drawbacks. Long-term global CO₂ storage generates high-pressure environments, poses leakage risks, and requires extensive monitoring. This review evaluates the potential conversion of CO₂ storage site into methane deposits and the mitigation of overpressure risks through the activity of indigenous organisms. Furthermore, the analysis characterizes potential reservoir types, various CH₄ production pathways, microbial communities, and microbial survivability under extreme conditions, alongside the side effects of microorganisms and the overall potential of methanogenic technology. Bacterial conversion of CO₂ to methane is considered as the most effective sequestration process. Depleted oil and gas reservoirs have been identified as optimal sites for CO₂ sequestration and microbial methane restoration, with Methanomicrobiales, Methanobacteriales, and Methanococcales identified as the primary taxa suitable for microbial methane production. Optimized nutritient and substrate delivery can enhance the viability of these organisms under reservoir conditions. Integrating CO₂ sequestration with indigenous microorganisms for microbial methane (CH₄) production represents an attractive waste recycling strategy. This approach is expected not only to reduce CO₂ emissions and environmental impact, but also to expand methane deposits to meet future energy demands.</p>